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Cpwwp2a

Web“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for … WebMar 17, 2024 · These results suggest that cPWWP2A is a molecular sponge for miR-29b. To verify that cPWWP2A/miR-29b regulates the NLRP3 signaling pathway, C2C12 cells …

Targeting pericyte-endothelial cell crosstalk by circular RNA …

WebMar 26, 2024 · The sequence of cPWWP2A obtained by Sanger sequencing was consistent with the sequence of cPWWP2A annotated in circBase (Fig. 1B). cPWWP2A was resistant to RNase R digestion, whereas linear PWWP2A mRNA was easily degraded (Fig. 1C). qRT-PCR assays showed that retinal cPWWP2A expression was significantly higher in … WebMay 16, 2024 · For example, circRNA cPWWP2A could upregulate the expression of occludin, angiopoietin-1, and sirtuin-1 (markers regulating retinal vascularization and endothelial cell function), thereby ... hofors camping https://markgossage.org

circRNA_010383 Acts as a Sponge for miR-135a, and Its …

WebPericyte-derived cPWWP2A affects pericyte coverage and vascular integrity through interacting with miR-579 and its target genes, including angiopoietin 1/occludin/SIRT1. Our study thus reveals a critical role of cPWWP2A-mediated signaling in retinal microvascular dysfunction and implies potential therapeutic benefit with high-level expression ... WebMar 21, 2024 · Protein attributes for PWWP2A Gene. Size: 755 amino acids. Molecular mass: 81960 Da. Protein existence level: PE1. Quaternary structure: Component of a … WebIntroduction. Diabetes mellitus is a chronic disease worldwide. According to an epidemiological survey released by the World Health Organization, the global prevalence of diabetes among adults (20–79 years) will increase from 6.4% in 2010 to 7.7% in 2030, which means that the number of affected adults will increase from 285 million to 439 million. 1 … huawei cloud snapshot connection

Targeting pericyte-endothelial cell crosstalk by circular RNA-cPWWP2A …

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Cpwwp2a

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WebMar 26, 2024 · The sequence of cPWWP2A obtained by Sanger sequencing was consistent with the sequence of cPWWP2A annotated in circBase (Fig. 1B). cPWWP2A was … WebMar 26, 2024 · Knockout of cPWWP2A and mimicking its downstream target miR579 could further increase the number of avascular zone, pericyte loss and microangioma. later, they found that overexpression of cPWWP2A ...

Cpwwp2a

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WebIn addition, silencing cPWWP2A also exacerbated retinal inflammation (Liu et al., 2024). Mechanistically, cPWWP2A acting as a miRNA sponge sequesters and inhibits the activity of miR-579, thereby upregulating the expression of target genes of miR-579 including angiopoietin 1, occludin, and SIRT1 in pericytes (Liu et al., 2024). WebMar 17, 2024 · The link between cPWWP2A and miR-29b was confirmed by dual-luciferase assays showing a strong binding of miR-29b to cPWWP2A (Fig. (Fig.1l). 1l). The expression of miR-29b was increased in ischemic muscle (Supplementary Fig. 9a), which was contrary to that of cPWWP2A. These results suggest that cPWWP2A is a molecular sponge for …

WebMar 26, 2024 · Knockout of cPWWP2A and mimicking its downstream target miR579 could further increase the number of avascular zone, pericyte loss and microangioma. later, … Web(1) This study doesn't well clarify why the most significantly up-regulated CircRNA mmu _circ_0000254 the fold change of which is 160.581 is excluded,while the cPWWP2A the …

Webgulated cPWWP2A leads to abnormal pericyte–EC crosstalk in vitro and retinal vascular dysfunction in vivo, suggesting that cPWWP2A is an important regulator in diabetes … WebA study on diabetic microvascular complications found that exosomes can carry circular RNAs-cPWWP2A, an endogenous miR-579 sponge, and indirectly mediate the function of retinal vessels in patients with diabetes through different expression levels of cPWWP2A and miR-579. 148 However, it has been found that the level of platelet-rich plasma ...

WebIt is shown that diabetes-related stress up-regulates cPWWP2A expression in pericytes but not in ECs, and a mechanism by which pericyte and ECs communicate is unveiled, which may offer opportunities for treating diabetic microvascular complications. Significance The crosstalk between vascular endothelial cells (ECs) and pericytes in the microvascular is …

WebApr 12, 2024 · article 2a. limitation on foreign claims. chapter 55. actions, suits and arbitration; judicial sale. huawei cloud storage full how to deleteWebNational Center for Biotechnology Information huawei cloud singaporeWebDec 3, 2024 · CPWWP2A-miR-579 interaction in DR. Dysregulated functions of retinal microvasculature that comprise endothelial cells and pericytes have been reported to be a major cause of vascular leakage in patients with DR.94 An elevated expression of cPWWP2A in pericytes was reported by Liu et al. in 2024, suggesting their role in DR. … hoforshallenWebSep 24, 2024 · Significantly, forced overexpression of cPWWP2A largely attenuated DEX-induced cytotoxicity in OB-6 cells (Fig. 2 C–E). Download : Download high-res image … hoforshus mina sidorWeb70802 Ensembl ENSG00000170234 ENSMUSG00000044950 UniProt Q96N64 Q69Z61 RefSeq (mRNA) NM_001130864 NM_001267035 NM_052927 NM_001349732 … hofors ishallWeb“cPWWP2A-miR-579-Angiopoietin 1/Occluding/SIRT1” in DR. This study may provide new insight into the potential use the cPWWP2A-miR-579 as new treatment strategies for DR. Although the quick development of high-throughput RNA deep sequencing, along with bioinformatics predictor tools, will enable a faster discovery of the pathway interac- hofors msWebMar 1, 2024 · In addition, cPWWP2A inhibited the tumor suppressor Rb1-mediated NLRP3 inflammasome pathway through the miR-29b/ CDK6 axis in C2C12 cells (Wang et al., 2024b). In another research, UMSC-Exos could ... huawei cloud storage free