WebObjectives To evaluate the efficacy and safety of different doses of filgotinib, an oral Janus kinase 1 inhibitor, as monotherapy in patients with active rheumatoid arthritis (RA) and previous inadequate response to methotrexate (MTX). Methods In this 24-week phase IIb study, patients with moderately to severely active RA were randomised (1:1:1:1) to … WebCapt. Edward Levett Darwin (12 April 1821 – 23 April 1901) was the author under the pen-name High Elms of The Game-preserver's Manual: Containing Instructions in All That Relates to Getting Up and Maintaining a Good Head of Game (1859), which shows keen observation of the habits of various animals, and went through at least five editions. …
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