Webb17 feb. 2024 · The chemokine Cxcl10 has been associated with poor prognosis in breast cancer, but the mechanism is not well understood. Our previous study has shown that CXCL10 was repressed by the ING4 tumor suppressor, suggesting a potential inverse functional relationship. We thus investigated a role for Cxcl10 in the context of ING4 … Webb15 feb. 2024 · A long guanine-rich oliogonucleotide sequence can form multiple G-quadruplex (G4) tandem individuals in a single molecule with internal G4-G4 (inG4-G4) interfaces. The interface can exist at the stacked (s-inG4-G4) or unstacked (us-inG4-G4) state, dependent of the G4 conformation and environment. Be …
Formazione - Ordine degli Ingegneri di Siena
WebbING4, also termed p29ING4, and ING5, also termed p28ING5, belong to the inhibitor of growth (ING) family of type II tumor suppressors. ING4 acts as an E3 ubiquitin ligase to induce ubiquitination of the p65 subunit of NF-kappaB and inhibit the transactivation of NF-kappaB target genes. It also induces apoptosis through a p53 dependent pathway ... Webb13 nov. 2024 · Overall, our findings suggest that Ing4 plays a crucial role in the regulation of hematopoiesis and provides key tools for further identification and characterization of Ing4 pathways and functions. Given the role of Ing4 in both normal hematopoiesis and cancer, this gene likely has a critical role in regulation of stem cell self-renewal and … flannel bush image
Formazione - Ordine degli Ingegneri di Arezzo
WebbEmail: Password: Password dimenticata? Webb26 aug. 2013 · Shiseki et al. (2003) showed that overexpression of ING4 or ING5 ( 608525) in cancer cell lines diminished colony-forming efficiency, decreased cell population in S phase, and induced p53 ( 191170 )-dependent apoptosis. Both ING4 and ING5 activated the WAF1 ( 116899) promoter and induced WAF1 expression. WebbPer offrirti il miglior servizio possibile, questo sito utilizza cookies. Continuando la navigazione nel sito autorizzi l’uso dei cookies can sampling methodologies be biased