WebDisclosed are a phosphamide derivative, a method for manufacturing the same, and uses thereof Particularly disclosed are a compound shown by general formula (I) as well as a pharmaceutically acceptable salt or stereisomer (I) thereof, wherein, G, L, Q and s are as defined in the description. WebJul 4, 2024 · Cyclophosphamide is a medication primarily used in the management and treatment of neoplasms, including multiple myeloma, sarcoma, and breast cancer. Cyclophosphamide is a nitrogen mustard that exerts its anti-neoplastic effects through alkylation. This activity reviews the indications, contraindica …
Phosphonamide - an overview ScienceDirect Topics
WebAug 26, 2024 · The general design strategy for sensing is the nucleophilic attack by the chemodosimeter molecule (bearing –NH 2 /–OH functional groups) to the electrophilic phosphorous center of DCP, to form a phosphate ester or phosphamide compounds, then suppressing the photo induced electron transfer process and affording fluorescence turn … WebCyclophosphamide is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell-cycle non-specific. There are several … taphtar plain bdo
National Center for Biotechnology Information
WebAug 1, 2007 · Purpose: Alkylating agents and the anti-CD20 monoclonal antibody rituximab are among appropriate choices for the primary treatment of symptomatic patients with Waldenström macroglobulinemia (WM), and they induce at least a partial response in 30% to 50% of patients. To improve these results, we designed a phase II study that included … WebNov 15, 2024 · Phosphamide modification gave these three compounds liver specificity, and the MTT assay showed that they did not have obvious cell toxicity at 10 μM (10-fold … taphuan lms vnedu